Weekly Journal of Sickle Cell Disease Publication Update
Stay current with the latest sickle cell research, regulatory updates, and guidelines.
Pulmonary function among children and young adults with sickle cell disease: the potential role of air pollution
To examine whether higher ambient concentrations of criteria air pollutants were associated with increased odds of abnormal pulmonary function among children and young adults with sickle cell disease (SCD).
Retinal Optical Coherence Tomography as a Noninvasive Biomarker of Silent Cerebral Infarcts in Pediatric Sickle Cell Disease
To investigate the association between silent cerebral infarcts (SCI) and retinal ischemic injury detected by optical coherence tomography (OCT) in children and young adults with sickle cell disease (SCD), and...
Biomarker profiles in distinct clinical subphenotypes of SCD: an explorative study
To evaluate glomerular, tubular, and endothelial biomarkers in patients with SCD, focusing primarily on differences between hemolysis-dominant (HD) and vaso-occlusion–dominant (VOD) subphenotypes.
Lapses in clinic appointment attendance in young children with sickle cell disease
To examine the prevalence of lapsed attendance (LA) among young children with sickle cell disease (SCD), identify factors statistically associated with gaps in SCD clinic attendance, and characterize caregiver-reported reasons...
“I think if we don’t eat well, we will be sicker”: a qualitative perspective on contributing factors to diet intake and nutrition among adults living with sickle cell disease in the United States
To examine intrapersonal and environmental facilitators and barriers influencing dietary intake among adults living with sickle cell disease (SCD) using qualitative interviews within a mixed-methods study, and to better understand...
Efficacy and safety of osivelotor in participants with sickle cell disease in a 12-week, phase 2, multicenter, open-label, dose-finding trial and extension study
To evaluate the efficacy, safety, and optimal dosing of osivelotor, a sickle hemoglobin (HbS) polymerization inhibitor, in adults with sickle cell disease (SCD), and to assess the durability of response...
Sudden death caused by plastic bronchitis as a complication of acute chest syndrome in a child with sickle cell disease
To describe a rare case of plastic bronchitis complicating acute chest syndrome (ACS) in a child with sickle cell disease (SCD) and highlight the importance of early recognition of this...
Placental histopathology in the Townes humanized mouse model of SCD
To characterize placental histopathology in the Townes humanized mouse model of sickle cell disease (SCD) and determine how closely the observed placental abnormalities resemble those reported in pregnancies affected by...
Ciliary protein ARL13b detected on RBCs as a potential indicative biomarker of vaso-occlusive crisis and disease severity in SCD: a retrospective pilot study
To evaluate whether red blood cell (RBC)-bound ADP-ribosylation factor-like protein 13b (ARL13b), a cilia-associated protein, is associated with future vaso-occlusive crises (VOC) and disease severity in sickle cell disease (SCD),...
Criterion validity of the functional status and pain assessment scale versus pain and length of stay in hospitalized adults with SCD
To evaluate the criterion validity of the Functional Status Pain Assessment (FSPA), a 10-item functional assessment tool, by examining its relationship with pain intensity and hospital length of stay (LOS)...