Weekly Journal of Sickle Cell Disease Publication Update
Stay current with the latest sickle cell research, regulatory updates, and guidelines.
Lapses in clinic appointment attendance in young children with sickle cell disease
To examine the prevalence of lapsed attendance (LA) among young children with sickle cell disease (SCD), identify factors statistically associated with gaps in SCD clinic attendance, and characterize caregiver-reported reasons...
“I think if we don’t eat well, we will be sicker”: a qualitative perspective on contributing factors to diet intake and nutrition among adults living with sickle cell disease in the United States
To examine intrapersonal and environmental facilitators and barriers influencing dietary intake among adults living with sickle cell disease (SCD) using qualitative interviews within a mixed-methods study, and to better understand...
Efficacy and safety of osivelotor in participants with sickle cell disease in a 12-week, phase 2, multicenter, open-label, dose-finding trial and extension study
To evaluate the efficacy, safety, and optimal dosing of osivelotor, a sickle hemoglobin (HbS) polymerization inhibitor, in adults with sickle cell disease (SCD), and to assess the durability of response...
Sudden death caused by plastic bronchitis as a complication of acute chest syndrome in a child with sickle cell disease
To describe a rare case of plastic bronchitis complicating acute chest syndrome (ACS) in a child with sickle cell disease (SCD) and highlight the importance of early recognition of this...
Placental histopathology in the Townes humanized mouse model of SCD
To characterize placental histopathology in the Townes humanized mouse model of sickle cell disease (SCD) and determine how closely the observed placental abnormalities resemble those reported in pregnancies affected by...
Ciliary protein ARL13b detected on RBCs as a potential indicative biomarker of vaso-occlusive crisis and disease severity in SCD: a retrospective pilot study
To evaluate whether red blood cell (RBC)-bound ADP-ribosylation factor-like protein 13b (ARL13b), a cilia-associated protein, is associated with future vaso-occlusive crises (VOC) and disease severity in sickle cell disease (SCD),...
Criterion validity of the functional status and pain assessment scale versus pain and length of stay in hospitalized adults with SCD
To evaluate the criterion validity of the Functional Status Pain Assessment (FSPA), a 10-item functional assessment tool, by examining its relationship with pain intensity and hospital length of stay (LOS)...
Diphenhydramine is not associated with poor outcomes among hospitalized people with sickle cell disease
To evaluate whether intravenous (IV) diphenhydramine use is associated with new-onset acute chest syndrome (ACS) among adults hospitalized for vaso-occlusive episodes (VOE), while adjusting for inpatient opioid exposure.
Outcomes of a Sustained Multi-Disciplinary Advisory Group in Advancing Sickle Cell Care and Research
To describe the outcomes of a sustained, collaborative, long-term multidisciplinary health provider andcommunity advisory group focused on improving sickle cell disease (SCD) care, education, and research.
Cerebral Microhemorrhages in a Mouse Model of Sickle Cell Disease
To investigate cerebral microvascular injury in a humanized mouse model of sickle cell disease (SCD) and examine the relationship between cerebral microhemorrhages (CMHs) and mast cells.