Weekly Journal of Sickle Cell Disease Publication Update
Stay current with the latest sickle cell research, regulatory updates, and guidelines.
A public health led, statewide approach to improving emergency department care for individuals with sickle cell disease — North Carolina
The initiative seeks to address variation in ED care during vaso-occlusive episodes (VOEs) through statewide collaboration among public health, SCD clinicians, emergency medicine teams, health systems, and community partners. The...
Blind Spots: Patient Knowledge and Practices around Ocular Complications in Sickle Cell Disease
To assess adults’ knowledge of ocular complications associated with SCD and their reported eye-care practices, including screening and responses to acute visual symptoms. The study focuses on sickle cell retinopathy...
Treating pain in SCD: design of a randomized crossover controlled Mediterranean diet feeding study
The study will investigate whether a MedDiet affects chronic non-vaso-occlusive pain, gut microbiome composition, and microbial metabolites in adults with SCD. It explores diet and the gut–brain axis as potential...
Trajectories of emergency department use among adolescents and young adults with sickle cell disease in North Carolina
To describe age-related patterns of emergency department (ED) utilization among adolescents and young adults (AYAs) with sickle cell disease (SCD) in North Carolina and examine associations with sociodemographic characteristics and...
Beyond the blood disorder: unlocking the individual and community factors that build resilience in adults with sickle cell
To examine individual and community factors associated with resilience among adults with SCD, including individual, healthcare, relationship, community, and economic factors, guided by Aday’s Framework for Studying Vulnerable Populations.
Community leads the way: the essential role of CBO-anchored community health worker partnerships in strengthening hydroxyurea uptake and sickle cell disease care
To evaluate a citywide, multi-component initiative intended to increase hydroxyurea (HU) use among children with sickle cell disease (SCD), with particular attention to the role of partnerships between community-based organizations...
Pulmonary function among children and young adults with sickle cell disease: the potential role of air pollution
To examine whether higher ambient concentrations of criteria air pollutants were associated with increased odds of abnormal pulmonary function among children and young adults with sickle cell disease (SCD).
Retinal Optical Coherence Tomography as a Noninvasive Biomarker of Silent Cerebral Infarcts in Pediatric Sickle Cell Disease
To investigate the association between silent cerebral infarcts (SCI) and retinal ischemic injury detected by optical coherence tomography (OCT) in children and young adults with sickle cell disease (SCD), and...
Biomarker profiles in distinct clinical subphenotypes of SCD: an explorative study
To evaluate glomerular, tubular, and endothelial biomarkers in patients with SCD, focusing primarily on differences between hemolysis-dominant (HD) and vaso-occlusion–dominant (VOD) subphenotypes.
Lapses in clinic appointment attendance in young children with sickle cell disease
To examine the prevalence of lapsed attendance (LA) among young children with sickle cell disease (SCD), identify factors statistically associated with gaps in SCD clinic attendance, and characterize caregiver-reported reasons...