Weekly Journal of Sickle Cell Disease Publication Update
Stay current with the latest sickle cell research, regulatory updates, and guidelines.
Levagen+ Ameliorates Hyperalgesia in a Mouse Model of Sickle Cell Disease
To evaluate whether palmitoylethanolamide (PEA), a non-intoxicating lipid mediator related to cannabinoid signaling, could reduce pain hypersensitivity and inflammatory activity in sickle cell disease (SCD).
Transition to Adult Sickle Cell Disease Care: A Project ECHO Learning Series for Healthcare Professionals
To evaluate whether a structured Project ECHO virtual learning series could improve healthcare professionals’ knowledge and confidence in facilitating transition from pediatric to adult care for patients with sickle cell...
Etavopivat Reduces Incidence of Vaso-occlusive Crises in Patients With Sickle Cell Disease: Hibiscus Trial Phase 2 Results through 52 Weeks
To evaluate the efficacy and safety of etavopivat, a selective activator of red blood cell pyruvate kinase, in patients with sickle cell disease (SCD). Etavopivat improves red cell energy metabolism...
Transition to Adult Sickle Cell Disease Care: A Project ECHO Learning Series for Healthcare Professionals
To evaluate whether a structured Project ECHO virtual learning series could improve healthcare professionals’ knowledge and confidence in facilitating transition from pediatric to adult care for patients with sickle cell...
Soluble C5b-9 as a Biomarker for Hemolysis-Associated Complications in Sickle Cell Disease
To evaluate soluble C5b-9 (sC5b-9), a marker of terminal complement activation, as a biomarker for hemolysis-associated complications in sickle cell disease (SCD).
Placental Contributions to Pregnancy Outcomes in the Townes Mouse Model of Sickle Cell Disease
To investigate how placental pathology contributes to adverse pregnancy outcomes in sickle cell disease (SCD).
Non-Genotoxic Conditioning to Improve Donor Chimerism in a Mismatched Murine Transplant Model for Sickle Cell Disease
To evaluate whether non-genotoxic antibody-drug conjugate (ADC) conditioning can support donor hematopoietic engraftment in a murine sickle cell disease (SCD) transplant model.
A Phase 1b, Open-label, Multiple-Dose Study Evaluating Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Pociredir in Patients With Sickle Cell Disease (SCD): Trial Design
To assess safety, pharmacokinetics (PK), pharmacodynamics (PD), and biologic activity of pociredir in patients with SCD, including effects on fetal hemoglobin (HbF) and hemolysis.
Breast cancer screening in women with SCD: a single-center exploratory study
To evaluate breast cancer screening utilization and mammographic characteristics among women living with sickle cell disease (SCD).
Preliminary observations on cerebral blood flow and pain sensitivity in adults with SCD
To explore the relationship between cerebral blood flow (CBF) and pain sensitivity in adults with sickle cell disease (SCD).