Weekly Journal of Sickle Cell Disease Publication Update
Stay current with the latest sickle cell research, regulatory updates, and guidelines.
Transition to Adult Sickle Cell Disease Care: A Project ECHO Learning Series for Healthcare Professionals
To evaluate whether a structured Project ECHO virtual learning series could improve healthcare professionals’ knowledge and confidence in facilitating transition from pediatric to adult care for patients with sickle cell...
Soluble C5b-9 as a Biomarker for Hemolysis-Associated Complications in Sickle Cell Disease
To evaluate soluble C5b-9 (sC5b-9), a marker of terminal complement activation, as a biomarker for hemolysis-associated complications in sickle cell disease (SCD).
Placental Contributions to Pregnancy Outcomes in the Townes Mouse Model of Sickle Cell Disease
To investigate how placental pathology contributes to adverse pregnancy outcomes in sickle cell disease (SCD).
Non-Genotoxic Conditioning to Improve Donor Chimerism in a Mismatched Murine Transplant Model for Sickle Cell Disease
To evaluate whether non-genotoxic antibody-drug conjugate (ADC) conditioning can support donor hematopoietic engraftment in a murine sickle cell disease (SCD) transplant model.
A Phase 1b, Open-label, Multiple-Dose Study Evaluating Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Pociredir in Patients With Sickle Cell Disease (SCD): Trial Design
To assess safety, pharmacokinetics (PK), pharmacodynamics (PD), and biologic activity of pociredir in patients with SCD, including effects on fetal hemoglobin (HbF) and hemolysis.
Breast cancer screening in women with SCD: a single-center exploratory study
To evaluate breast cancer screening utilization and mammographic characteristics among women living with sickle cell disease (SCD).
Preliminary observations on cerebral blood flow and pain sensitivity in adults with SCD
To explore the relationship between cerebral blood flow (CBF) and pain sensitivity in adults with sickle cell disease (SCD).
An international multicenter cohort shows sickle cell disease is no longer uniformly associated with low body weight, with persistent undernutrition alongside increasing overweight and obesity across age groups, genotypes, and countries.
To characterize body mass index (BMI) distribution and associated clinical factors in individuals with sickle cell disease across diverse global settings.
Elevated ambient nitrogen dioxide (NO₂) levels were associated with greater odds of abnormal pulmonary function tests in children and young adults with sickle cell disease (SCD), highlighting an environmental factor that may influence respiratory health in this population.
To evaluate whether ambient air pollution exposures, particularly criteria pollutants, are associated with abnormal pulmonary function tests (PFTs) among young people living with SCD.
A 5-year-old girl with sickle cell disease (Hb SS) and poor hydroxyurea adherence developed concurrent warm autoimmune hemolytic anemia (wAIHA), splenic sequestration, and hyperhemolysis/delayed hemolytic transfusion reaction after transfusion, illustrating the complexity of immune-mediated hemolysis and the role of multidisciplinary, phenotype-matched intervention.
To present a clinical case illustrating the diagnostic and therapeutic challenges when multiple severe hemolytic complications of SCD converge in a single pediatric patient.