Weekly Practice Update
Interviews with 19 older adults with sickle cell disease (SCD) reveals aging challenges and wisdom for management of sickle cell and healthy aging.
To describe the aging experiences and priorities of adults with SCD aged ≥50 so clinicians can deliver better care for this growing population.
Study finds improvement in emergency medicine (EM) residents’ knowledge after a 40-minute lecture on sickle cell disease (SCD)
To evaluate whether a brief, structured educational intervention could improve EM residents’ knowledge and perceptions about SCD.
National Alliance of Sickle Cell Centers (NASCC) practice recommendations establish standardized criteria for sickle cell disease (SCD) care delivery
NASCC used a systematic, modified RAND/UCLA Delphi method to develop consensus-driven clinical practice recommendations for SCD. This process incorporated expert judgment alongside data from the Globin Research Network for Data...
Survey of U.S. Clinicians’ attitudes toward palliative care (PC) to enhance the quality of life for patients with sickle cell disease (SCD)
To assess clinician attitudes, referral practices, and barriers affecting the integration of PC in SCD management.
Studies Indicate That Dalcetrapib Shows in Vitro Antisickling Effects and Strong RBC Partitioning for β-chain Cys93 Allosteric Regulation of Hemoglobin
Review preclinical and translational evidence for targeting β-chain Cysteine-93 (βCys93) as an allosteric regulator of hemoglobin affinity and as a potential antisickling strategy distinct from α-chain modulators (e.g., voxelotor).
Study Finds Rare Atypical Bacteria in Pediatric SCD ACS, Underscoring Limited Utility of Empiric Macrolides
To determine the prevalence of atypical bacterial pathogens in children with sickle cell disease (SCD) presenting with acute chest syndrome (ACS) or pneumonia.
Study Suggests Psychological Stress Destabilizes Blood Pressure Control in Sickle Cell Disease, Potentially Contributing to Vaso-Occlusive Crises
To investigate whether hydroxyurea (HU) modulates expression of transcriptional repressors that silence fetal γ-globin genes, thereby clarifying the molecular mechanism of HbF induction.
Hydroxyurea Decreases BCL11A and ZBTB7A/LRF Expression in Erythroid Cells, Including Human Progenitors, Providing Support in Raising Fetal Hemoglobin Levels in Sickle Cell Disease
To investigate whether hydroxyurea (HU) modulates expression of transcriptional repressors that silence fetal γ-globin genes, thereby clarifying the molecular mechanism of HbF induction.
Neutrophil Phagocytic Activity Found Impaired in A Study of Sickle Cell Patients With Transfusion History
To compare the ability of neutrophils from individuals with sickle cell anemia (SCA) versus controls to perform phagocytosis (uptake of foreign particles), and to assess how transfusion exposure affects neutrophil...
Study Offers Preliminary Validity for Functional Status-Based Pain Assessment (FSPA) in Adults Hospitalized With Sickle Cell Disease Vaso-Occlusive Crises.
Evaluate preliminary validity of a daily functional status pain assessment (FSPA) tool for adults with sickle cell disease (SCD) during vaso-occlusive crises (VOCs), with the aim of enhancing discharge readiness...