NASCC used a systematic, modified RAND/UCLA Delphi method to develop consensus-driven clinical practice recommendations for SCD.
To assess clinician attitudes, referral practices, and barriers affecting the integration of PC in SCD management.
Review preclinical and translational evidence for targeting β-chain Cysteine-93 (βCys93) as an allosteric regulator of hemoglobin affinity and as a potential antisickling strategy distinct from α-chain modulators (e.g., voxelotor).
To determine the prevalence of atypical bacterial pathogens in children with sickle cell disease (SCD) presenting with acute chest syndrome (ACS) or pneumonia.
Assess hemodynamic responses to mental and psychological stress in adults with sickle cell anemia (HbSS) using beat-to-beat blood pressure monitoring.
To investigate whether hydroxyurea (HU) modulates expression of transcriptional repressors that silence fetal γ-globin genes, thereby clarifying the molecular mechanism of HbF induction.
To compare the ability of neutrophils from individuals with sickle cell anemia (SCA) versus controls to perform phagocytosis (uptake of foreign particles), and to assess how transfusion exposure affects neutrophil...
Evaluate preliminary validity of a daily functional status pain assessment (FSPA) tool for adults with sickle cell disease (SCD) during vaso-occlusive crises (VOCs), with the aim of enhancing discharge readiness...
To identify hematological, biochemical, and metabolic biomarkers associated with sickle cell anemia (SCA) severity and to assess machine learning models' ability to predict disease severity accurately.
Assess prevalence of nocturnal hemoglobin desaturation (NHD) among adults with severe sickle cell disease (SCD) who receive chronic red blood cell exchange (RCE) transfusions.